During the third wave of COVID-19, frontline clinicians are struggling to manage the accumulation of stress of the prior 15 months and keep burnout at bay. Whereas their initial efforts to protect the community were met with enthusiasm, many of those shows of support have waned. Vaccinations bring an element of hope but also new tensions. Meanwhile, inside hospital ICUs, patients are younger, usually unvaccinated, and sicker than ever before. After months of caring for intubated and unresponsive patients, the Wellstar Kennestone ICU team begins caring for Carlos, an unvaccinated man who is "wide awake." Through his charisma, Carlos begins lifting the spirits of the caregivers.